Theming is hard, Drupal produces tons of unnecessary markup which makes it overly complicated for designers to implement their designs in the elegant and simple way they want to.
By building Angular.js based applications - powered by mean.io we can tap in to the information in a Drupal site and let the designer work freely with any markup they want.
I'll cover the next topics in my talk...

• What's mean.io and why do people love it (3000+ stars in github)
• How the drupal MEAN module works and how it lets designers use whatever markup they want...
• How to create mean applications that can be embedded within blocks and panes in your site.
• Building Single page applications with a Drupal backend.

I've blogged about this subject here - http://www.linnovate.net/blog/mean-io-and-drupal